The 49ers’ offensive line and running backs are incredibly banged up. That makes life difficult for San Francisco quarterback Brock Purdy. While the Lions are dealing with their own rash of injuries, Jared Goff and Detroit deliver and exact revenge in a game where they have much more at stake.

Check out these five of the best anytime TD prop bets for this NFL matchup between the 49ers and Lions on MNF. Find key stats and betting trends for this game.

Here are the two critical matchups to watch on MNF between Detroit Lions and San Francisco 49ers in Week 17, including Penei Sewell against Nick Bosa.

It’s 49ers vs Lions in Week 17 of the 2024 NFL season. Here’s how to watch, including time, channel, TV schedule and streaming info.

Listing our expert Penn Live picks of the best prop bets and odds available for tonight's Monday Night Football NFC matchup between the Lions and 49ers.

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Newsweek Sports' expert predictions for Detroit Lions vs. San Francisco 49ers on Monday Night Football Week 17.

The Lions have a huge game against the Vikings next week that will determine the NFC North title and top seed in the conference, which brings with it a first-round playoff bye and home-field advantage throughout the playoffs.

The Lions face the Vikings next Sunday night in a winner-take-all matchup for the division title, but first need to get by a San Francisco 49ers team that is looking toward to off