Following the significant losses of players due to injury and illness, including Brandon Aiyuk, San Francisco 49ers head coach Kyle Shanahan said he

San Francisco 49ers wide receiver Brandon Aiyuk underwent tests that confirmed he suffered a season-ending knee injury on Sunday.

At an up-and-down 3-4, the reigning NFC champion San Francisco 49ers can’t be reliably counted on as a bona fide contender. That makes Brandon Aiyuk’s season-ending knee injury an outright disaster for a Bay Area constellation of football superstars still chasing an elusive Lombardi Trophy.

Kareem Hunt rushed for two touchdowns in the first half on Sunday as the Kansas City Chiefs became the only unbeaten team in the NFL with a 28-18 victory over the San Francisco 49ers in Santa Clara, Calif.

Patrick Mahomes overcame two interceptions to deliver a few big plays with his feet and the Kansas City Chiefs remained the league's only undefeated team, beating the San Francisco 49ers 28-18 Sunday in a Super Bowl rematch.

Wide receiver Brandon Aiyuk sustained what the San Francisco 49ers believe is a season-ending knee injury Sunday, compounding their sorrowful feelings after being dealt a 28-18 loss to the two-time defending champion Kansas City Chiefs.